Famous in the 1960s for its rugby and football achievements, it was not called a high school until education reforms of the early 1970s introduced comprehensive schools. In the early days under the headship of Mr J.F. Grundy, the school had a single pupil styled School Captain. There were also house captains and prefects, each class elected a Class Captain in the first year who remained so for the next three years. In the then fourth and final year, the boys and girls were each placed into single sex classes. A fifth year class was introduced in 1962 but only for external pupils coming from other schools and they stayed on until age 16.

In 2004, St Cuthbert's became a Business and Enterprise College as specialist schools became central to the development of secondary education.  Linked to the school's specialism the school (supported by the European Community through the European Regional Development Fund, the Coalfields Regeneration Trust, the British Government’s Single Regeneration Budget and St.Helens Metropolitan Borough Council) operated its own hotel and café. Lindisfarne House was a hotel built onto the school by Farne Limited. It was a National and International Exchange Accommodation Centre offering accommodation for national and international schools exchanges, visiting students, amateur sports organisations and other national and international visitors and groups. In 2004, the Hotel was re-opened by the Earl and Countess of Wessex. The hotel closed in November 2014.

In 2015, after a period of consultation with pupils, parents, staff and governors the school name changed to St Cuthbert’s Catholic High School. The building previously occupied by the hotel has been redeveloped to provide seven state-of-the-art classrooms.

Three generations of “Cuthie’s Kids” have now passed through the school since the mid-1950s under the leadership of seven head teachers. 

The original houses of the school were: Lourdes, Walsingham, Carmel and Fatima; each being named after a Marian shrine where Our Lady was reputed to have manifested herself to chosen children. The houses are now Dignity, Faith, Hope and Unity; each is represented by its colour and motto and focuses on an area of the world, has adopted a charity and has its own House patron.

The school’s original motto, Laus Deo Semper from the Latin meaning "Praise always to God", is the motto of many saints, especially those in the monastic tradition. “Live life in all its fullness” comes from the words of Jesus “I have come in order that you might have life—life in all its fullness.” (John 10:10).